Disclaimer

This website and its contents is intended for residents within the EU and Canada only. Information relating to the USA approved product can be found at www.exogen.com

For full prescribing and indication information please click here.

References

  1. Instructions for use
  2. Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. (1994) Acceleration of Tibial Fracture-Healing by Non-Invasive, Low-Intensity Pulsed Ultrasound. J Bone Joint Surg 79-A (1): 26-34
  3. Nolte PA, van der Krans A, Patka P, Janssen IMC, Ryaby JP, Albers GHR. (2001) Low-intensity pulsed ultrasound in the treatment of nonunions. J Trauma 51(4): 693-703
  4. Azuma Y., Ito M., Harada Y., Takagi H., Ohta T., Jingushi S. Low intensity pulsed ultrasound accelerates rat femoral fracture healing by acting on the various cellular reactions in the fracture callus, J. Bone Miner. Res. 16 (4) (2001) 671–680
  5. Rubin, C., Bolander, M., Ryaby, J. P. & Hadjiargyrou, M. (2001) The Use of Low-Intensity Ultrasound to Accelerate the Healing of Fractures J. Bone Jt. Surg. 83-A, 259–270
  6. Siska PA, Gruen GS, Pape HC. External adjuncts to enhance fracture healing: What is the role of ultrasound? Injury. 2008;39:1095–5.
  7. Internal S&N Company data
  8. K.S. Leung, W.S. Lee, H.F. Tsui, P.P.L. Liu, W.H. Cheung, Complex tibial fracture outcomes following treatment with low-intensity pulsed ultrasound, Ultrasound Med. Biol. 30 (3) (2004) 389–395
  9. Coughlin MJ, Smith BW, Traughber P. The evaluation of the healing rate of subtalar arthrodeses, part 2: the effect of low-intensity ultrasound stimulation. Foot Ankle Int. 2008 Oct;29(10):970-7.
  10. Pounder NM, Harrison AJ. Low intensity pulsed ultrasound for fracture healing: a review of the clinical evidence and the associated biological mechanism of action. Ultrasonics. 2008 Aug;48(4):330-8. Epub 2008 Mar 27.
  11. Post Market Approval Data
  12. Cook SD, Ryaby JP, McCabe J, Frey JJ, Heckman JD, Kristiansen TK (1997) Acceleration of Tibia and Distal Radius Fracture Healing in Patients Who Smoke. Clin. Orthop. Rel. Res. 337: 198–207.
  13. Ayan ,I Aslan G, Çomelekoglu Ü, Yilmaz N, Çolak M.The effect of low-intensity pulsed sound waves delivered by the Exogen device on Staphylococcus aureus morphology and genetics Acta Orthop Traumatol Turc 2008;42(4):272-277
  14. Li Y (2004) Cellular and molecular mechanisms of low intensity pulsed ultrasound in cultured human macrophages – implication in wound healing. Ph.D. Thesis, University of Ulm, Germany
  15. Ebisawa K, Hata K, Okada K, Kimata K, Ueda M, Torii S, Watanabe H (2004) Ultrasound enhances transforming growth factor beta-mediated chondrocyte differentiation of human mesenchymal stem cells. Tiss. Eng. 10 (5-6): 921-929
  16. Ridgway JN, Kaneez S, Unsworth JM, Harrison AJ (2005) Osteogenic gene expression in response to pulsed low intensity ultrasound. Poster presentation, ORS, Washington DC.
  17. Leung KS, Cheung WH, Zhang C, Lee KM, Lo HK. (2004) Low intensity pulsed ultrasound stimulates osteogenic activity of human periosteal cells. Clin Orthop Rel Res 418: 253-259
  18. Yang K-H, Parvizi J, Wang S-J, Lewallen DG, Kinnick RR, Greenleaf JF, Bolander ME (1996) Exposure to low-intensity ultrasound increases aggrecan gene expression in a rat femur fracture model. J. Orthop. Res. 14 (5) 802-809
  19. Parvizi J, Wu C-C, Lewallen DG, Greenleaf JF, Bolander ME (1999) Low-intensity ultrasound stimulates proteoglycan synthesis in rat chondrocytes by increasing aggrecan gene expression. J. Bone Joint Surg. 17: 488-494
  20. Vaughan NM, Sivapitchai AR, Bader DL, Knight MM (2005) Low intensity pulsed ultrasound stimulated GAG synthesis in chondrocytes in agarose. ORS Annual Meeting, Washington DC.
  21. Kokubu T, Matsui N, Fujioka H, Tsunoda M, Mizuno K (1999) Low intensity pulsed ultrasound exposure increases prostaglandin E2 production via the induction of cyclooxygenase-2 mRNA in mouse osteoblasts. Biochem. Biophys. Res. Comm. 256: 284-287
  22. Sena K, Leven RM, Mazhar K, Sumner DR, Virdi AS (2005) Early gene response to low-intensity pulsed ultrasound in rat osteoblastic cells. Ultrasound in Med. & Biol. 31: 703-708
  23. Naruse K, Miyauchi A, Itoman M, Mikuni-Takagaki Y (2003) Distinct Anabolic Response of Osteoblast to Low-Intensity Pulsed Ultrasound. J. Bone & Miner. Res. 18(2): 360-369
  24. Chen Y-J, Wang C-J, Yang KD, Chang P-R, Huang H-C, Huang Y-T, Sun Y-C, Wang F-S (2003)Pertussis toxin-sensitive Gαi protein and ERK-dependent pathways mediate ultrasound promotion of osteogenic transcription in human osteoblasts. FEBS Lett 554: 154-158
  25. Wang F-S, Kuo Y-R, Wang C-J, Yang KD, Chang P-R, Huang Y-T, Huang H-C, Sun Y-C, Yang Y-J, Chen Y-J (2004) Nitric oxide mediates ultrasound-induced hypoxia-inducible factor-1α activation and vascular endothelial growth factor-A expression in human osteoblasts. Bone 35: 114-123
  26. Premarket Approval P900009/Supplement 6, Summary of safety and effectiveness data: low intensity pulsed ultrasound device for the noninvasive treatment of nonunions. Exogen◊, a Smith & Nephew Company, 2000.

Get our FREE Patient information brochure here.

Download now

It is never too early or too late to use
EXOGEN to heal your broken bone.4

Find out more, get in touch today!

Phone: 1-855-771-0606

or complete the enquiry form below:

CAPTCHA

 

Please enter the characters from the image into the box.